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  • 產品名稱： Recombinant SARS-CoV-2 (2019-nCoV) NSP1
  • 產品貨號： CSEP02461COV
  • 貨期： 現貨
  • 價格與訂購： 2880
  • 數量：
    庫存： 10
  • 規(guī)格： 100μg
  • 產品信息
  • 如何訂購
    產品名稱（Product name）
    Recombinant SARS-CoV-2 (2019-nCoV) NSP1
    貨號（Catalog#）
    CSEP02461COV
    描述（description）
    Recombinant SARS-CoV-2 NSP1 is produced by E.coli expression system and the target gene encoding Met1-Gly180 is expressed with N-His Tag
    表達系統（Expression system）
    E.coli
    種屬（Species）
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
    Accession #
    YP_009725297.1
    別名（Alternative names)
    SARS-CoV 2 nsp1,SARS-CoV 2 Leader protein
    預測分子量（Predicted Molecular Mass）
    21.94kDa
    實際分子量（Actual Molecular Mass）
    22-23kDa
    純度（Purity）
    >90% as determined by SDS-PAGE
    內毒素（Endotoxin level）
    Please contact with the lab for this information
    制劑（Formulation）
    Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5
    運輸方式（Shipping）
    In general, proteins are shipped out with blue ice unless customers require otherwise.
    穩(wěn)定性&儲存（Stability &Storage）
    Use a manual defrost freezer and avoid repeated freeze thaw cycles.
    Store at 2 to 8 °C for one week .
    Store at -20 to -80 °C for twelve months from the date of receipt.
    復溶（Reconstitution）
    Please refer to the instraction in the hard copy of COA.
    應用（Application）
    Immunogen
    背景（Background）
    The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ～30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
    Note
    For research use only .